Publications

Find our lab member's complete list of publications at Pubmed.

Selected publications from our lab members

2024

  • Adeno-associated virus-based gene therapy treats inflammatory kidney disease in mice. Wu G°, Liu S°, Hagenstein J, Alawi M, Hengel FE, Schaper M, Akyüz N, Liao Z, Wanner N, Tomas NM, Failla AV, Dierlamm J, Körbelin J*, Lu S*, Huber TB*.
    The Journal of Clinical Investigation. 2024 Aug 15;134(17):e174722. doi: 10.1172/JCI174722. °,* equal contribution

    Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact. Toma K, Zhao M, Zhang S, Wang F, Graham HK, Zou J, Modgil S, Shang WH, Tsai NY, Cai Z, Liu L, Hong G, Kriegstein AR, Hu Y, Körbelin J, Zhang R, Liao YJ, Kim TN, Ye X, Duan X.
    Cell. May 23;187(11):2767-2784.e23. doi: 10.1016/j.cell.2024.04.010. Epub 2024 May 10.

    Proteomics of mouse brain endothelium uncovers dysregulation of vesicular transport pathways during aging. Todorov-Völgyi K, González-Gallego J, Müller SA, Beaufort N, Malik R, Schifferer M, Todorov MI, Crusius D, Robinson S, Schmidt A, Körbelin J, Bareyre F, Ertürk A, Haass C, Simons M, Paquet D, Lichtenthaler SF, Dichgans M.
    Nature Aging. 2024 Apr;4(4):595-612. doi: 10.1038/s43587-024-00598-z. Epub 2024 Mar 22

2023

  • Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension. Isobe S, Nair RV, Kang HY, Wang L, Moonen JR, Shinohara T, Cao A, Taylor S, Otsuki S, Marciano DP, Harper RL, Adil MS, Zhang C, Lago-Docampo M, Körbelin J, Engreitz JM, Snyder MP, Rabinovitch M.
    Nature Communications. 2023 Nov 21;14(1):7578. doi: 10.1038/s41467-023-43039-y.

    Blood T cell phenotypes correlate with fatigue severity in post-acute sequelae of COVID-19 Pink I, Hennigs JK, Ruhl L, Sauer A, Boblitz L, Huwe M, Fuge J, Falk CS, Pietschmann T, de Zwaan M, Prasse A, Kluge S, Klose H, Hoeper MM, Welte T.
    Infection. 2023 Nov 4. doi: 10.1007/s15010-023-02114-8. Online ahead of print.

    Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown. Aydin S, Pareja J, Schallenberg VM, Klopstein A, Gruber T, Page N, Bouillet E, Blanchard N, Liblau R, Körbelin J, Schwaninger M, Johnson AJ, Schenk M, Deutsch U, Merkler D, Engelhardt B.
    Nature Communications. 2023 May 30;14(1):3106. doi: 10.1038/s41467-023-38703-2.

2022

  • Gene therapy targeting the blood-brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency. Sundaram SM, Arrulo Pereira A, Müller-Fielitz H, Köpke H, De Angelis M, Müller TD, Heuer H, Körbelin J, Krohn M, Mittag J, Nogueiras R, Prevot V, Schwaninger M.
    Brain. 2022 Dec 19;145(12):4264-4274. doi: 10.1093/brain/awac243.

    Respiratory muscle dysfunction in long-COVID patients. Hennigs JK, Huwe M, Hennigs A, Oqueka T, Simon M, Harbaum L, Körbelin J, Schmiedel S, Schulze Zur Wiesch J, Addo MM, Kluge S, Klose H.
    Infection. 2022 Oct;50(5):1391-1397.

    Adeno-Associated Virus-Mediated Gene Transfer of Inducible Nitric Oxide Synthase to an Animal Model of Pulmonary Hypertension. Remes A*, Körbelin J*, Arnold C, Rowedder C, Heckmann M, Mairbäurl H, Frank D, Korff T, Frey N, Trepel M, Müller OJ.
    Human Gene Therapy. 2022 Sep;33(17-18):959-967. doi: 10.1089/hum.2021.230. * equal contribution

2021

  • Invasion of phagocytic Galectin 3 expressing macrophages in the diabetic brain disrupts vascular repair. Mehina EMF, Taylor S, Boghozian R, White E, Choi SE, Cheema MS, Korbelin J, Brown CE.
    Science Advances. 2021 Aug 18;7(34):eabg2712.

    Efferocytosis fuels malignant pleural effusion through TIMP1. Zhao L, Giannou AD, Xu Y, Shiri AM, Liebold I, Steglich B, Bedke T, Zhang T, Lücke J, Scognamiglio P, Kempski J, Woestemeier A, Chen J, Agalioti T, Zazara DE, Lindner D, Janning M, Hennigs JK, Jagirdar RM, Kotsiou OS, Zarogiannis SG, Kobayashi Y, Izbicki JR, Ghosh S, Rothlin CV, Bosurgi L, Huber S, Gagliani N.
    Science Advances. 2021 Aug 13;7(33):eabd6734.

    PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism . Ren AA, Snellings DA, Su YS, Hong CC, Castro M, Tang AT, Detter MR, Hobson N, Girard R, Romanos S, Lightle R, Moore T, Shenkar R, Benavides C, Beaman MM, Müller-Fielitz H, Chen M, Mericko P, Yang J, Sung DC, Lawton MT, Ruppert JM, Schwaninger M, Körbelin J, Potente M, Awad IA, Marchuk DA, Kahn ML.
    Nature. 2021 Jun;594(7862):271-276. doi: 10.1038/s41586-021-03562-8. Epub 2021 Apr 28.

2020

  • PPARy-p53-Mediated Vasculoregenerative Program to Reverse Pulmonary Hypertension. Hennigs JK, Cao A, Li CG, Shi M, Mienert J, Miyagawa K, Körbelin J, Marciano DP, Chen PI, Roughley M, Elliott MV, Harper RL, Bill MA, Chappell J, Moonen JR, Diebold I, Wang L, Snyder MP, Rabinovitch M.
    Circulation Research. 2020 Dec 16. Online ahead of print.

    Inactivation of Adeno-Associated Viral Vectors by Oxidant-Based Disinfectants. Korte J, Mienert J, Hennigs JK, Körbelin J.
    Human Gene Therapy. Published Online:6 Nov 2020.

    Endothelium-Macrophage Crosstalk Mediates Blood-Brain Barrier Dysfunction in Hypertension. Santisteban M, Ahn S, Lane D, Faraco G, Garcia-Bonilla L, Racchumi G, Poon C, Schaeffer S, Segarra S, Körbelin J, Anrather J, Iadecola C
    Hypertension. 2020;76(3):795-807.

2019

  • The P2-receptor-mediated Ca2+ signalosome of the human pulmonary endothelium - implications for pulmonary arterial hypertension. Hennigs JK, Lüneburg N, Stage A, Schmitz M, Körbelin J, Harbaum L, Matuszcak C, Mienert J, Bokemeyer C, Böger RH, Kiefmann R, Klose H.
    Purinergic Signaling. 2019 Sep;15(3):299-311.

    Smooth Muscle Contact Drives Endothelial Regeneration by BMPR2-Notch1-Mediated Metabolic and Epigenetic Changes. Miyagawa K, Shi M, Chen PI, Hennigs JK, Zhao Z, Wang M, Li CG, Saito T, Taylor S, Sa S, Cao A, Wang L, Snyder MP, Rabinovitch M.
    Circulation Research. 2019 Jan 18;124(2):211-224.

    Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1. Yousef H, Czupalla CJ, Lee D, Chen MB, Burke AN, Zera KA, Zandstra J, Berber E, Lehallier B, Mathur V, Nair RV, Bonanno LN, Yang AC, Peterson T, Hadeiba H, Merkel T, Körbelin J, Schwaninger M, Buckwalter MS, Quake SR, Butcher EC, Wyss-Coray T.
    Nature Medicine. 2019 Jun;25(6):988-1000.

2018

  • Pathobiology, pathology and genetics of pulmonary hypertension: Update from the Cologne Consensus Conference 2018. Olschewski A, Berghausen EM, Eichstaedt CA, Fleischmann BK, Grünig E, Grünig G, Hansmann G, Harbaum L, Hennigs JK, Jonigk D, Kuebler WM, Kwapiszewska G, Pullamsetti SS, Stacher E, Weissmann N, Wenzel D, Schermuly RT.
    International Journal of Cardiology. 2018 Dec 1;272S:4-10.

    Myeloperoxidase aggravates pulmonary arterial hypertension by activation of vascular Rho-kinase. Klinke A, Berghausen E, Friedrichs K, Molz S, Lau D, Remane L, Berlin M, Kaltwasser C, Adam M, Mehrkens D, Mollenhauer M, Manchanda K, Ravekes T, Heresi GA, Aytekin M, Dweik RA, Hennigs JK, Kubala L, Michaëlsson E, Rosenkranz S, Rudolph TK, Hazen SL, Klose H, Schermuly RT, Rudolph V, Baldus S.
    JCI Insight. 2018 Jun 7;3(11). pii: 97530.

    Role of Toll-like receptors and interferon regulatory factors in different experimental heart failure models of diverse etiology: IRF7 as novel cardiovascular stress-inducible factor. Becher PM, Hinrichs S, Fluschnik N, Hennigs JK, Klingel K, Blankenberg S, Westermann D, Lindner D.
    PLoS One. 2018 Mar 14;13(3):e0193844.

2017

  • Upregulation of Human Endogenous Retrovirus-K Is Linked to Immunity and Inflammation in Pulmonary Arterial Hypertension. Saito T, Miyagawa K, Chen SY, Tamosiuniene R, Wang L, Sharpe O, Samayoa E, Harada D, Moonen JAJ, Cao A, Chen PI, Hennigs JK, Gu M, Li CG, Leib RD, Li D, Adams CM, Del Rosario PA, Bill M, Haddad F, Montoya JG, Robinson WH, Fantl WJ, Nolan GP, Zamanian RT, Nicolls MR, Chiu CY, Ariza ME, Rabinovitch M.
    Circulation. 2017 Nov 14;136(20):1920-1935.

    Optimization of design and production strategies for novel adeno-associated viral display peptide libraries. Körbelin J, Hunger A, Alawi M, Sieber T, Binder M, Trepel M.
    Gene Therapy. 2017 Aug;24(8):470-481.

    Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertension. Chen PI, Cao A, Miyagawa K, Tojais NF, Hennigs JK, Li CG, Sweeney NM, Inglis AS, Wang L, Li D, Ye M, Feldman BJ, Rabinovitch M.
    JCI Insight. 2017 Jan 26;2(2):e90427.

2016

  • A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases. Körbelin J, Dogbevia G, Michelfelder S, Ridder DA, Hunger A, Wenzel J, Seismann H, Lampe M, Bannach J, Pasparakis M, Kleinschmidt JA, Schwaninger M, Trepel M.
    EMBO Molecular Medicine. 2016 Jun 1;8(6):609-25.

    Pulmonary Targeting of Adeno-associated Viral Vectors by Next-generation Sequencing-guided Screening of Random Capsid Displayed Peptide Libraries. Körbelin J, Sieber T, Michelfelder S, Lunding L, Spies E, Hunger A, Alawi M, Rapti K, Indenbirken D, Müller OJ, Pasqualini R, Arap W, Kleinschmidt JA, Trepel M.
    Molecular Therapy 2016 Jun;24(6):1050-1061.

    In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and Its Target Slug. Hopper RK, Moonen JR, Diebold I, Cao A, Rhodes CJ, Tojais NF, Hennigs JK, Gu M, Wang L, Rabinovitch M.
    Circulation. 2016 May 3;133(18):1783-94.

2015

  • BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension. Diebold I*, Hennigs JK*, Miyagawa K, Li CG, Nickel NP, Kaschwich M, Cao A, Wang L, Reddy S, Chen PI, Nakahira K, Alcazar MA, Hopper RK, Ji L, Feldman BJ, Rabinovitch M.
    Cell Metabolism. 2015 Apr 7;21(4):596-608 *contributed 2/3 & 1/3 of experiments

    RNA Sequencing Analysis Detection of a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension. Rhodes CJ, Im H, Cao A, Hennigs JK, Wang L, Sa S, Chen PI, Nickel NP, Miyagawa K, Hopper RK, Tojais NF, Li CG, Gu M, Spiekerkoetter E, Xian Z, Chen R, Zhao M, Kaschwich M, Del Rosario PA, Bernstein D, Zamanian RT, Wu JC, Snyder MP, Rabinovitch M.
    American Journal of Respiratory and Critical Care Medicine. 2015 Aug 1;192(3):356-66.

    Transcription Factor Runx2 Promotes Aortic Fibrosis and Stiffness in Type 2 Diabetes Mellitus. Raaz U, Schellinger IN, Chernogubova E, Warnecke C, Kayama Y, Penov K, Hennigs JK , Salomons F, Eken S, Emrich FC, Zheng WH, Adam M, Jagger A, Nakagami F, Toh R, Toyama K, Deng A, Buerke M, Maegdefessel L, Hasenfuß G, Spin JM, Tsao PS.
    Circulation Research. 2015 Aug 28;117(6):513-24

    Treatment of multifocal breast cancer by systemic delivery of dual-targeted adeno-associated viral vectors. Trepel M*, Körbelin J*, Spies E, Heckmann MB, Hunger A, Fehse B, Katus HA, Kleinschmidt JA, Müller OJ, Michelfelder S.
    Gene Therapy. 2015 Oct;22(10):840-7. *equal contibution

Find our lab member's complete list of publications at Pubmed