ENDomics Lab
- Endothelial Research Group

Endothelial dysfunction is a hallmark of most vascular diseases, affecting all major organs such as the lung or the brain. Pulmonary vascular diseases (PVD) and pulmonary arterial hypertension in particular are vasoproliferative conditions characterized by severe endothelial dysfunction in the lung. Endothelial dysfunction in the brain is associated with numerous neurological disorders such as Alzheimer's disease. We apply an integrative multi-omics approach supplemented by in silico-based bioinformatics and functional cell biology to decipher the pathological molecular signatures of endothelial cells in vascular diseases and cancer. By developing organo-specific AAV vectors specifically-targeting endothelial cells we are able to study the molecular basis of endothelial dysfunction and evaluate the potential of new endothelium-based pharmacological and gene therapies.